Final Draft
International Standard
ISO/FDIS 19290
Cigarettes — Determination of tobacco specific nitrosamines in the mainstream smoke with a smoking regime according to ISO 3308 (standard smoking regime)— Method using high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS)
Reference number
ISO/FDIS 19290
Edition 3
© ISO 2026
Final Draft International Standard
Under development
This draft is in the approval phase.
Will replace ISO 19290:2021

Abstract

This document specifies a method for the quantification of four tobacco specific nitrosamines (TSNAs) in the total particulate matter of mainstream cigarette smoke by using reversed phase high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS). The quantified TSNAs are: N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

General information

  • Status
     : Under development
    Stage
    : Final text received or FDIS registered for formal approval [50.00]
  • Edition
     : 3
  • Technical Committee :
    ISO/TC 126
    ICS :
    65.160 
  • RSS updates

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